PCBP1 Polyclonal Antibody

PCBP1

This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

37kDa

1mg/mL

Unconjugated

WB 1:500-1:2000 IHC 1:50-1:100 IF 1:50-1:200

A synthetic peptide of human PCBP1 (NP_006187.2).

37kDa

Affinity purification

PCBP1;HEL-S-85;HNRPE1;HNRPX;hnRNP-E1;hnRNP-X

Q15365