p16 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-40264-20uL | 20uL | £120.00 |
Quantity:
| E-AB-40264-60uL | 60uL | £160.00 |
Quantity:
| E-AB-40264-120uL | 120uL | £230.00 |
Quantity:
| E-AB-40264-200uL | 200uL | £331.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Rat
Applications:
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
p16
Background:
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53.
Buffer:
PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.
Concentration:
0.82 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:50-1:200 IF 1:100-1:200
Immunogen:
Recombinant Rat Cyclin-dependent kinase inhibitor 2A protein
Purification method:
Antigen Affinity Purification
Target Synonym:
CCM2;CDK4 inhibitor p16 INK4;CDK4I;CDKN2;CDKN2A;Cell cycle negative regulator beta;CMM2;Cyclin dependent kinase 4 inhibitor A;Cyclin dependent kinase inhibitor 2A (melanoma p16 inhibits CDK4);Cyclin Dependent Kinase Inhibitor 2A
UNIProt ID:
Q9R0Z3