NPHS1 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-70211-60uL | 60uL | £184.00 |
Quantity:
| E-AB-70211-120uL | 120uL | £251.00 |
Quantity:
| E-AB-70211-200uL | 200uL | £351.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Mouse
Application: Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
NPHS1
Background:
This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.In Western blots, nephrin antibodies generated against the two terminal extracellular Ig domains of recombinant human nephrin recognized a 180-kDa protein in lysates of human glomeruli and a 150-kDa protein in transfected COS-7 cell lysates.
Buffer:
PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
Concentration:
1.3 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:1000-1:2000
Immunogen:
KLH conjugated Synthetic peptide corresponding to Mouse Nephrin
Purification method:
Affinity purification
Target Synonym:
CNF;Nephrin;Nephrosis 1 congenital Finnish type;Nephrosis 1;congenital;Finnish type (nephrin);NPHN;NPHN;NPHS 1;Nphs1;Renal glomerulus specific cell adhesion receptor;Renal glomerulus-specific cell adhesion receptor
UNIProt ID:
Q9QZS7