MDM2 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-64556-60uL | 60uL | £210.00 |
Quantity:
| E-AB-64556-120uL | 120uL | £291.00 |
Quantity:
| E-AB-64556-200uL | 200uL | £431.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
MDM2
Background:
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Calculated MW:
11-14kDa/24-55kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000
Immunogen:
Recombinant fusion protein of human MDM2 (NP_002383.2).
ObservedMW:
55kDa
Purification method:
Affinity purification
Target Synonym:
MDM2;ACTFS;HDMX;hdm2
UNIProt ID:
Q00987
References
- https://www.mdpi.com/2049316