JNK1 Polyclonal Antibody

JNK1

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

35kDa/44kDa/48kDa

1mg/mL

Unconjugated

WB 1:500-1:2000 IHC 1:100-1:200 IF 1:50-1:200

Recombinant fusion protein of human JNK1 (NP_620635.1).

50kDa

Affinity purification

MAPK8;JNK;JNK-46;JNK1;JNK1A2;JNK21B1/2;PRKM8;SAPK1;SAPK1c

P45983