IL10 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-70235-60uL | 60uL | £184.00 |
Quantity:
| E-AB-70235-120uL | 120uL | £251.00 |
Quantity:
| E-AB-70235-200uL | 200uL | £351.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Mouse
- Rat
Applications:
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
IL10
Background:
Interleukin (IL)-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
Buffer:
PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
Concentration:
150 ug/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:200-1:1000, IF 1:200-1:1000
Immunogen:
KLH conjugated Synthetic peptide corresponding to IL-10
Purification method:
Affinity purification
Target Synonym:
CSIF;Cytokine synthesis inhibitory factor;GVHDS;IL 10;IL-10;IL10;IL10;IL10A;Interleukin 10;Interleukin-10;MGC126450;MGC126451;T-cell growth inhibitory factor;TGIF
UNIProt ID:
P18893 ,P29456
References
- https://www.hindawi.com/journals/omcl/2022/8244497/