HLA-B Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-64350-60uL | 60uL | £210.00 |
Quantity:
| E-AB-64350-120uL | 120uL | £291.00 |
Quantity:
| E-AB-64350-200uL | 200uL | £431.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
HLA-B
Background:
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Calculated MW:
40kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:1000-1:2000 IHC 1:50-1:200
Immunogen:
A synthetic peptide of human HLA-B (NP_005505.2).
ObservedMW:
40kDa
Purification method:
Affinity purification
Target Synonym:
HLA-B;AS;B-4901;HLAB;Bw-47;Bw-50;SPDA1
UNIProt ID:
P01889