HIRA Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-62250-60uL | 60uL | £224.00 |
Quantity:
| E-AB-62250-120uL | 120uL | £317.00 |
Quantity:
| E-AB-62250-200uL | 200uL | £465.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
HIRA
Background:
This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Calculated MW:
89kDa/111kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000 IHC 1:100-1:200
Immunogen:
Recombinant fusion protein of human HIRA (NP_003316.3).
ObservedMW:
112kDa
Purification method:
Affinity purification
Target Synonym:
HIRA;DGCR1;TUP1;TUPLE1
UNIProt ID:
P54198