FOXO1 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-70143-60uL | 60uL | £184.00 |
Quantity:
| E-AB-70143-120uL | 120uL | £251.00 |
Quantity:
| E-AB-70143-200uL | 200uL | £351.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Mouse
- Rat
Application: Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
FOXO1
Background:
FOXO1,also named as FOXO1A,FKHR and FKH1,is a member of the FOXO subfamily of Forkhead transcription factors. FOXO1 is a transcription factor which acts as a regulator of cell responses to oxidative stress. FOXO1 interacts with LRPPRC and SIRT1. In the presence of KIRT1,FOXO1 mediates down-regulation of cyclin D1 and up-regulation of CDKN1B levels which are required for cell transition from proliferative growth to quiescence. FOXO1 contains three predicted protein kinase B phosphorylation sites (Thr-24,Ser-256,and Ser-319) that are conserved in other FOXO proteins. The t(2;13) and the variant t(1;13) translocations generate PAX3/FKHR and PAX7/FKHR fusion proteins respectively. The resulting protein is a transcriptional activator. Defects in FOXO1 are a cause of rhabdomyosarcoma type 2 (RMS2).
Buffer:
PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
Calculated MW:
78-82kDa
Concentration:
0.58 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000
Immunogen:
Recombinant protein corresponding to Mouse FOXO1
ObservedMW:
78kDa
Purification method:
Affinity purification
Target Synonym:
FKH 1;FKH1;FKHR;Forkhead (Drosophila) homolog 1 (rhabdomyosarcoma);Forkhead box O1;Forkhead box protein O1;Forkhead box protein O1A;Forkhead in rhabdomyosarcoma;Forkhead;Drosophila;homolog of;in rhabdomyosarcoma;FoxO transcription factor;foxo1;FOXO1;FOXO1A;OTTHUMP00000018301
UNIProt ID:
Q9R1E0,G3V7R4