FBLN5 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-63037-60uL | 60uL | £210.00 |
Quantity:
| E-AB-63037-120uL | 120uL | £291.00 |
Quantity:
| E-AB-63037-200uL | 200uL | £431.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Immunofluorescence (IF)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
FBLN5
Background:
The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3).
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Calculated MW:
50kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000 IF 1:50-1:100
Immunogen:
Recombinant fusion protein of human FBLN5 (NP_006320.2).
ObservedMW:
72kDa
Purification method:
Affinity purification
Target Synonym:
FBLN5;ADCL2;ARCL1A;ARMD3;DANCE;EVEC;FIBL-5;HNARMD;UP50;fibulin-5
UNIProt ID:
Q9UBX5