DROSHA Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-62428-60uL | 60uL | £210.00 |
Quantity:
| E-AB-62428-120uL | 120uL | £291.00 |
Quantity:
| E-AB-62428-200uL | 200uL | £431.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
DROSHA
Background:
This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer.
Buffer:
PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Calculated MW:
138kDa/151kDa/155kDa/159kDa
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000
Immunogen:
A synthetic peptide of human DROSHA
ObservedMW:
159KDa
Purification method:
Affinity purification
Target Synonym:
DROSHA;ETOHI2;HSA242976;RANSE3L;RN3;RNASE3L;RNASEN
UNIProt ID:
Q9NRR4