Caspase-3 Polyclonal Antibody

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Elabscience
Product Code: E-AB-60017
Product Group: Primary Antibodies
Supplier: Elabscience
CodeSizePrice
E-AB-60017-60uL60uL£210.00
Quantity:
E-AB-60017-120uL120uL£291.00
Quantity:
E-AB-60017-200uL200uL£431.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunofluorescence (IF)
  • Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Documents

Further Information

Abbreviation:
Caspase-3
Background:
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Calculated MW:
31kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000 IF 1:50-1:200
Immunogen:
A synthetic peptide of human Caspase-3 (NP_004337.2).
ObservedMW:
15kDa/35kDa
Purification method:
Affinity purification
Target Synonym:
CPP32;CPP32B;SCA-1;Active Caspase 3;CASP3;active Caspase-3;Caspase 3;Caspase-3 p12;caspase-3
UNIProt ID:
P42574

References

  • https://onlinelibrary.wiley.com/doi/abs/10.1111/jre.12973
  • https://www.worldscientific.com/doi/abs/10.1142/S0192415X21500245
  • https://www.sciencedirect.com/science/article/pii/S0960076018302851
  • https://link.springer.com/article/10.1007/s43188-022-00148-y
  • https://www.sciencedirect.com/science/article/pii/S1382668920300880
  • https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/jat.4286
  • https://www.tandfonline.com/doi/abs/10.1080/13880209.2020.1765812
  • https://link.springer.com/article/10.1007/s12011-018-1587-4