(KO Validated) BAX Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-63606-60uL | 60uL | £224.00 |
Quantity:
| E-AB-63606-120uL | 120uL | £317.00 |
Quantity:
| E-AB-63606-200uL | 200uL | £465.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
BAX
Background:
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Calculated MW:
4kDa/12kDa/15kDa/18kDa/19kDa/21kDa/24kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000 IHC 1:100-1:200
Immunogen:
A synthetic peptide of human BAX (NP_620116.1).
ObservedMW:
20kDa
Purification method:
Affinity purification
Target Synonym:
BCL2L4;BAX
UNIProt ID:
Q07812
References
- https://www.sciencedirect.com/science/article/pii/S1382668922001739
- https://www.sciencedirect.com/science/article/pii/S0960076018302851