ATF6 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-70158-60uL | 60uL | £184.00 |
Quantity:
| E-AB-70158-120uL | 120uL | £251.00 |
Quantity:
| E-AB-70158-200uL | 200uL | £351.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
ATF6
Background:
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.
Buffer:
PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:200-1:1000
Immunogen:
KLH conjugated Synthetic peptide corresponding to Mouse ATF6
Purification method:
Affinity purification
Target Synonym:
Activating Transcription Factor 6;CAMP-Dependent Transcription Factor ATF-6 Alpha;Activating Transcription Factor 6 Alpha;Cyclic AMP-Dependent Transcription Factor ATF-6 Alpha;ATF6-Alpha;ACHM7;ATF6A.
UNIProt ID:
P18850,F6VAN0,G3V909