ALPL Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-70384-60uL | 60uL | £184.00 |
Quantity:
| E-AB-70384-120uL | 120uL | £251.00 |
Quantity:
| E-AB-70384-200uL | 200uL | £351.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
ALPL
Background:
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described.
Buffer:
PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
Calculated MW:
57kDa
Concentration:
200 ug/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000
Immunogen:
Recombinant protein corresponding to Mouse Alkaline Phosphatase
ObservedMW:
55kDa
Purification method:
Affinity purification
Target Synonym:
AKP2;Alkaline phosphatase liver/bone/kidney;Alkaline phosphatase liver/bone/kidney isozyme;Alkaline phosphatase tissue nonspecific isozyme;Alkaline phosphatase;tissue-nonspecific isozyme;Alkaline phosphomonoesterase;Alpl;AP TNAP;AP-TNAP;APTNAP;BAP;FLJ40094;FLJ93059;Glycerophosphatase;HOPS;Liver/bone/kidney type alkaline phosphatase;MGC161443;MGC167935;PHOA;PPBT;Tissue non specific alkaline phosphatase;Tissue nonspecific ALP;TNAP;TNSALP
UNIProt ID:
P05186,P09242,P08289