AIFM1 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-70181-60uL | 60uL | £184.00 |
Quantity:
| E-AB-70181-120uL | 120uL | £251.00 |
Quantity:
| E-AB-70181-200uL | 200uL | £351.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
AIFM1
Background:
This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10.
Buffer:
PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
Concentration:
0.98 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:300-1:1000
Immunogen:
KLH conjugated Synthetic peptide corresponding to Mouse AIF
Purification method:
Affinity purification
Target Synonym:
AIFM1;AIFM1;Apoptosis inducing factor 1;mitochondrial;Apoptosis inducing factor;Apoptosis inducing factor;mitochondrion associated;1;Apoptosis-inducing factor 1;CMTX4;COWCK;COXPD6;Harlequin;Hq;mAIF;MGC111425;MGC5706;mitochondrial;Neuropathy;axonal motor-sensory;with deafness and mental retardation;neuropathy;axonal;motor-sensory with deafness and mental retardation (Cowchock syndrome);PDCD 8;PDCD8;Programmed cell death 8 (apoptosis inducing factor);Programmed cell death 8;Programmed cell death 8 isoform 1;Programmed cell death 8 isoform 2;Programmed cell death 8 isoform 3;Programmed cell death protein 8;Programmed cell death protein 8 mitochondrial;Programmed cell death protein 8 mitochondrial precursor;Programmed cell death protein 8 mitochondrial precursor;Striatal apoptosis inducing factor
UNIProt ID:
O95831,Q9Z0X1,Q9JM53