Recombinant Rat IL-1 beta/IL1B Protein (mature form)(Active)
| Code | Size | Price |
|---|
| PKSR030425-20ug | 20ug | £368.00 |
Quantity:
| PKSR030425-100ug | 100ug | £1,029.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Regulatory Status: RUO
Application: Cell Culture
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
Store at < -20°C stable for 6 months after receipt. Please minimize freeze-thaw cycles.
Further Information
Abbreviation:
IL-1 beta;IL1B
Accession:
Q63264-1
Activity:
1. Measured in a cell proliferation assay using D10.G4. 1 mouse helper T cells. The ED50 for this effect is typically 30-120 pg/mL.
2. Measured by its ability to induce Interferon gamma secretion by human natural killer lymphoma NK-92 cells. The EC50 for this effect is typically 20-100ng/mL.
Background:
Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra). In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishment of successful pregnancy. Proinflammatory interleukin (IL)-1 gene polymorphisms associated with high levels of IL-1beta activity increase the risk for hypochlorhydria and distal gastric carcinoma. IL1B polymorphisms may be involved in susceptibility to SSc. Moreover, the IL2-384-G allele may be a marker for the limited phenotype of systemic sclerosis (SSc).
Calculated MW:
17.4 kDa
Expression Host:
E.coli
Formulation:
Lyophilized from sterile 40mM Tris, 0.15 M NaCl, pH 7.8
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
None
ObservedMW:
35 kDa
Purity:
> 98 % as determined by reducing SDS-PAGE.
Sequence:
Val 117-Ser 268
Target Synonym:
IL1B
UNIProt ID:
Q63264