Recombinant Human TRAIL R3/TNFRSF10C Protein (His Tag)(Active)
| Code | Size | Price |
|---|
| PKSH033128-10ug | 10ug | £116.00 |
Quantity:
| PKSH033128-50ug | 50ug | £195.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Application: Cell Culture
Shipping:
The product is shipped at ambient temperature. Upon receipt store it immediately at the storage temperature listed.
Storage:
Samples are stable for up to twelve months from date of receipt at -70°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Further Information
Abbreviation:
TRAIL R3;TNFRSF10C
Accession:
O14798
Activity:
Measured by its ability to inhibit TRAIL-mediated cytotoxicity using L-929 mouse fibroblast cells treated with TRAIL. The ED50 for this effect is 0.56 ng/ml.
Background:
Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C) is a glycosyl-phosphatidylinositol-linked membrane protein which binds TRAIL with high affinity. TNFRSF10C has the TRAIL-binding extracellular cysteine-rich domains; lacks the intracellular signaling domain. As a result; binding of TRAIL to TRAIL R3 doesn?t transduce an apoptosis signal. The expression of TRAIL R3 gene has been shown to protect cells bearing TRAIL R1 and/or TRAIL R2 from TRAIL-induced apoptosis.
Calculated MW:
21.8 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-6His
ObservedMW:
40 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Ala26-Ala221
Target Synonym:
Tumor Necrosis Factor Receptor Superfamily Member 10C;Antagonist Decoy Receptor for TRAIL/Apo-2L;Decoy TRAIL Receptor Without Death Domain;Decoy Receptor 1;DcR1;Lymphocyte Inhibitor of TRAIL;TNF-Related Apoptosis-Inducing Ligand Receptor 3;TRAIL Receptor 3;TRAIL-R3;TRAIL Receptor Without an Intracellular Domain;CD263;TNFRSF10C;DCR1;LIT;TRAILR3;TRID
UNIProt ID:
O14798