Recombinant Human TOLLIP Protein (His Tag)

Product Code: PKSH033125

Code	Size	Price

PKSH033125-10ug

10ug

£219.00

Quantity:

PKSH033125-50ug

50ug

£497.00

Quantity:

Prices exclude any Taxes / VAT

Overview

Host Type: Human

Regulatory Status: RUO

Shipping:

This product is provided as lyophilized powder which is shipped with ice packs.

Storage:

Samples are stable for up to twelve months from date of receipt at -70°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Documents

Further Information

Abbreviation:

TOLLIP

Accession:

Q9H0E2

Background:

Toll-Interacting Protein (TOLLIP) is a member of the tollip family. TOLLIP localizes to the cytoplasm. It contains one C2 domain and one CUE domain. TOLLIP is an inhibitory adaptor protein for Toll-like receptors (TLR). The Toll-like receptors pathway is a part of the immune system that recognize structurally conserved molecular patterns of microbial pathogens, resulting in an inflammatory immune response. TOLLIP constitutes a complex with Tom1 to regulate endosomal transferring of ubiquitinated proteins. TOLLIP can negative regulate Toll-like receptors signaling, which may limit the production of proinflammatory mediators during the process of inflammation and infection.

Calculated MW:

31.3 kDa

Endotoxin:

< 1.0 EU per ug of the protein as determined by the LAL method.

Expression Host:

E.coli

Formulation:

Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, 5mM EDTA, pH 7.2.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Fusion tag:

C-6His

ObservedMW:

31 kDa

Purity:

> 95 % as determined by reducing SDS-PAGE.

Sequence:

Ala2-Pro274

Target Synonym:

Toll-Interacting Protein;TOLLIP

UNIProt ID:

Q9H0E2