Recombinant Human PCBD1 Protein (His Tag)
| Code | Size | Price |
|---|
| PKSH032981-10ug | 10ug | £256.00 |
Quantity:
| PKSH032981-50ug | 50ug | £553.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage:
Samples are stable for up to twelve months from date of receipt at -70°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Further Information
Abbreviation:
PCBD1
Accession:
P61457
Background:
Pterin-4-α-Carbinolamine Dehydratase (PCBD1) is the founding member of the Pterin-4-α-Carbinolamine Dehydratase Family. PCBD1 is involved in Tetrahydrobiopterin biosynthesis. It seems to prevent the formation of 7-Pterins and accelerate the formation of Quinonoid-BH2. Furthermore, PCBD1 regulates the homodimerization of the transcription factor Hepatocyte Nuclear Factor 1 (HNF1) and enhances its transcriptional activity. Defects in PCBD1 are the cause of BH4-Deficient Hyperphenylalaninemia Type D (HPABH4D). HPABH4D is characterized by the excretion of 7-substituted Pterins in the urine of affected patients.
Calculated MW:
14.2 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
E.coli
Formulation:
Supplied as a 0.2 um filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM DTT, pH 8.0.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
N-6His
ObservedMW:
14 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Ala2-Thr104
Target Synonym:
Pterin-4-Alpha-Carbinolamine Dehydratase;PHS;4-Alpha-Hydroxy-Tetrahydropterin Dehydratase;Dimerization Cofactor of Hepatocyte Nuclear Factor 1-Alpha;DCoH;Dimerization Cofactor of HNF1;Phenylalanine Hydroxylase-Stimulating Protein;Pterin Carbinolamine Dehydratase;PCD;PCBD1;DCOH;PCBD
UNIProt ID:
P61457