Recombinant Human PDGF-BB Protein (His Tag)(Active)
| Code | Size | Price |
|---|
| PKSH030442-50ug | 50ug | £723.00 |
Quantity:
| PKSH030442-1mg | 1mg | £3,864.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Application: Enzyme-Linked Immunosorbent Assay (ELISA)
Shipping:
The product is shipped at ambient temperature. Upon receipt store it immediately at the storage temperature listed.
Storage:
Lyophilized protein should be stored at < -20°C though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months
Further Information
Abbreviation:
PDGF-BB
Accession:
NP_148937.1
Activity:
Immobilized human PDGFB at 10ug/mL (100uL/well) can bind human PDGFRβ-Fch, the EC50 of human PDGFRβ-Fch is 0.05-0.2 ug/mL.
Background:
Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.Binding of PDGFB to its receptor elicits a variety of cellular responses. In addition, PDGFB is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound.
Calculated MW:
14.3 kDa
Expression Host:
Yeast
Formulation:
Lyophilized from sterile PBS, 25 % Glycerol, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
N-His
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Ser82-Thr190
Target Synonym:
Platelet-Derived Growth Factor Subunit B;PDGF Subunit B;PDGF-2;Platelet-Derived Growth Factor B Chain;Platelet-Derived Growth Factor Beta Polypeptide;Proto-Oncogene c-Sis;Becaplermin;PDGFB;PDGF2;SIS