Recombinant Human NKG2DL/ULBP-1 Protein (His Tag)
| Code | Size | Price |
|---|
| PKSH032814-10ug | 10ug | £170.00 |
Quantity:
| PKSH032814-50ug | 50ug | £315.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
The product is shipped at ambient temperature. Upon receipt store it immediately at the storage temperature listed.
Storage:
Lyophilized protein should be stored at < -20°C though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months
Further Information
Abbreviation:
NKG2DL;ULBP-1
Accession:
Q9BZM6
Background:
ULBP1; also known as RAET1I and NKG2DL1; is a member of the ULBP/RAET1 gene family. ULBP1 plays an important role in immune responses; especially in cancer and infectious diseases; and is well-known to bind to NKG2D together with at least ULBP 2 and 3. These proteins are distantly related to major histocompatibility class I (MHC I) molecules; possessing the alpha 1 and alpha 2 Ig-like domains; but lacking the alpha 3 domain. Unlike MHC Class I; they have no capacity to bind peptide or interact with beta2-microglobulin. It can activate multiple signaling pathways in primary NK cells; gamma delta T cells; and CD8+ alpha beta T cells; resulting in the production of cytokines and chemokines.ULBP1 is expressed in wide range of tissues including heart; brain; lung; liver; bone marrow and some tumor cells; T-cells; B-cells; As an unconventional member of the MHC class I family; ULBP1 is able to interact with soluble CMV glycoprotein UL16 in CMV infected cells. The interaction with UL16 blocked the interaction with the NKG2D receptor; and thus might escape the immune surveillance. Furthermore; UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. The ULBP1 regulation may have implications for development of new therapeutic strategies against cancer cells.
Calculated MW:
23.3 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-6His
ObservedMW:
25-30 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Gly26-Pro215
Target Synonym:
NKG2D ligand 1;N2DL-1;NKG2DL1;ALCAN-beta;Retinoic acid early transcript 1I;UL16-binding protein 1;ULBP1
UNIProt ID:
Q9BZM6