Recombinant Human Interleukin-22/IL-22 Protein (C-hIgG2 Fc)(Active)
| Code | Size | Price |
|---|
| PKSH032632-10ug | 10ug | £219.00 |
Quantity:
| PKSH032632-50ug | 50ug | £497.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Application: Cell Culture
Shipping:
The product is shipped at ambient temperature. Upon receipt store it immediately at the storage temperature listed.
Storage:
Lyophilized protein should be stored at < -20°C though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months
Further Information
Abbreviation:
IL-22
Accession:
Q9GZX6
Activity:
Measured by its ability to induce IL-10 secretion in COLO 205 human colorectal adenocarcinoma cells. The ED50 for this effect is 90.41 ng/ml.
Background:
Interleukin-22(IL-22) is a member of a group of the IL-10 family; a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells. IL-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction. It can initiate and regulate innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 along with IL-17 likely plays a role in the coordinated response of both adaptive and innate immune systems. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. Biological activity of IL-22 is initiated by binding to a cell-surface complex consisting of IL-22R1 and IL-10R2 receptor chains. IL-22 biological activity is further regulated by interactions with a soluble binding protein; IL-22BP. IL-22BP and an extracellular region of IL-22R1 share sequence similarity. In some cases; the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by cytokine IL-17A.
Calculated MW:
43.4 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from a 0.2 um filtered solution of PBS, pH7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-hIgG2 Fc
ObservedMW:
50-62 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Ala34-Ile179
Target Synonym:
Interleukin-22;IL-22;Cytokine Zcyto18;IL-10-related T-cell-derived-inducible factor;IL-TIF;IL22;IL-D110;IL-TIF;ILTIF;TIFa;TIFIL-23;zcyto18
UNIProt ID:
Q9GZX6