Recombinant Human ITPase/ITPA Protein (His Tag)
| Code | Size | Price |
|---|
| PKSH032588-10ug | 10ug | £256.00 |
Quantity:
| PKSH032588-50ug | 50ug | £553.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage:
Lyophilized protein should be stored at < -20°C though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months
Further Information
Abbreviation:
ITPase;ITPA
Accession:
Q9BY32
Background:
Inosine Triphosphate Pyrophosphatase (ITPase) is a cytoplasmic enzyme that belongs to the HAM1 NTPase family. ITPase hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP) and deoxyinosine triphosphate (dITP) to the monophosphate nucleotide (IMP) and diphosphate. The ITPase enzyme acts as a homodimer and does not distinguish between the deoxy- and ribose forms. ITPase probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Defects in ITPase is thought to be inherited and is characterized by an over-accumulation of ITP in erythocytes, leukocytes and fibroblasts.
Calculated MW:
22.5 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
E.coli
Formulation:
Supplied as a 0.2 um filtered solution of 20mM Tris-HCl, pH 8.0.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-6His
ObservedMW:
21 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Ala2-Ala194
Target Synonym:
Inosine Triphosphate Pyrophosphatase;ITPase;Inosine Triphosphatase;Non-Canonical Purine NTP Pyrophosphatase;Non-Standard Purine NTP Pyrophosphatase;Nucleoside-Triphosphate Diphosphatase;Nucleoside-Triphosphate Pyrophosphatase;NTPase;Putative Oncogene Protein hlc14-06-p;ITPA;C20orf37
UNIProt ID:
Q9BY32