Recombinant Human GFRRA2 Protein ((Fc & His Tag)
| Code | Size | Price |
|---|
| PKSH032482-10ug | 10ug | £126.00 |
Quantity:
| PKSH032482-50ug | 50ug | £180.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
Lyophilized protein should be stored at < -20°C though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months
Further Information
Abbreviation:
GFRRA2
Accession:
O00451
Background:
GDNF family receptor alpha-2 is a glycosylphosphatidylinosito l (GPI)-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It also able to mediate GDNF signaling through the RET tyrosine kinase receptor. It acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1.
Calculated MW:
74.7 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from a 0.2 um filtered solution of 20mM Tris,150mM NaCl,pH8.0.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-Fc-6His
ObservedMW:
120 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Ser22-Ser441
Target Synonym:
GDNF Family Receptor Alpha-2;GDNF Receptor Alpha-2;GDNFR-Alpha-2;GFR-Alpha-2;GDNF Receptor Beta;GDNFR-Beta;Neurturin Receptor Alpha;NRTNR-Alpha;NTNR-Alpha;RET Ligand 2;TGF-Beta-Related Neurotrophic Factor Receptor 2;GFRA2;GDNFRB;RETL2;TRNR2
UNIProt ID:
O00451