Recombinant Human 4E-BP1/EIF4EBP1 Protein (His Tag)
| Code | Size | Price |
|---|
| PKSH032373-10ug | 10ug | £180.00 |
Quantity:
| PKSH032373-50ug | 50ug | £378.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
Lyophilized protein should be stored at < -20°C though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months
Further Information
Abbreviation:
4E-BP1;EIF4EBP1
Accession:
Q13541
Background:
Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 (4EBP1) is a number of the eIF4E-binding protein family. 4EBP1 regulates eIF4E activity by preventing its assembly into the eIF4F complex. 4EBP1 mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. Non-phosphorylated 4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E. 4EBP1 is phosphorylated in response to various signals including insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. 4EBP1 has a role in progression of breast neoplasms through cell signaling.
Calculated MW:
14.7 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
E.coli
Formulation:
Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
N-6His
ObservedMW:
17 kDa
Purity:
> 90 % as determined by reducing SDS-PAGE.
Sequence:
Met 1-Ile118
Target Synonym:
Eukaryotic Translation Initiation Factor 4E-Binding Protein 1;4E-BP1;eIF4E-Binding Protein 1;Phosphorylated Heat- and Acid-Stable Protein Regulated by Insulin 1;PHAS-I;EIF4EBP1;4E-BP1;4EBP1;BP-1
UNIProt ID:
Q13541