Recombinant Human Carboxylesterase 1/CES1 Protein (His Tag)
| Code | Size | Price |
|---|
| PKSH032167-10ug | 10ug | £536.00 |
Quantity:
| PKSH032167-50ug | 50ug | £833.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
The product is shipped on dry ice/blue ice. Upon receipt store it immediately at the storage temperature listed.
Storage:
Samples are stable for up to twelve months from date of receipt at -70°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Further Information
Abbreviation:
Carboxylesterase 1;CES1
Accession:
P23141-3
Background:
Carboxylesterase 1 (CES1) is a member of a large family of carboxylesterases that are responsible for the hydrolysis of ester and amide bonds. These enzymes have broad substrate specificity ranging from small molecule esters such as phenylester to long chain fatty acid esters and thioesters. They are major determinants of the pharmacokinetic behavior of most therapeutic agents containing an ester or amide bond. CES1 shares the serine hydrolase fold observed in other esterases. CES1 hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. CES1 participates in detoxification of drugs such as cocaine and heroin in serum and liver. It may also play a role in detoxification in the lung and/or protection of the central nervous system from ester or amide compounds.
Calculated MW:
61.1 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Supplied as a 0.2 um filtered solution of 20mM HAc-NaAc, 150mM NaCl, pH 4.0.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-6His
ObservedMW:
60 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
His19-Glu562
Target Synonym:
Liver Carboxylesterase 1;Acyl-Coenzyme A:Cholesterol Acyltransferase;ACAT;Brain Carboxylesterase hBr1;Carboxylesterase 1;CE-1;hCE-1;Cocaine Carboxylesterase;Egasyn;HMSE;Methylumbelliferyl-Acetate Deacetylase 1;Monocyte/Macrophage Serine Esterase;Retinyl Ester Hydrolase;REH;Serine Esterase 1;Triacylglycerol Hydrolase;TGH;CES1;CES2;SES1
UNIProt ID:
P23141