Recombinant Human APE1/APE Protein
| Code | Size | Price |
|---|
| PKSH032090-10ug | 10ug | £577.00 |
Quantity:
| PKSH032090-50ug | 50ug | £778.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
The product is shipped on dry ice/blue ice. Upon receipt store it immediately at the storage temperature listed.
Storage:
Lyophilized protein should be stored at < -20°C though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months
Further Information
Abbreviation:
APE1;APE
Accession:
P27695
Background:
Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases; APE1 cleaves the AP site to allow resynthesis and ligation to complete repair. APE1 stimulates the DNA binding activity of many transcription factors; which participate in cancer promotion and progression. APE1 regulates the redox state of multiple transcription factors; such as c-Jun; c-Fos; NF-kB; p53. APEN is also involved in calcium-dependent down-regulation of PTH expression.
Calculated MW:
35.6 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
E.coli
Formulation:
Supplied as a 0.2 um filtered solution of 10mM HEPES, 100mM KCl, 50% Glycerol, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
None
ObservedMW:
40 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Pro2-Leu318
Target Synonym:
DNA-(Apurinic or Apyrimidinic Site) Lyase;APEX Nuclease;APEN;Apurinic-Apyrimidinic Endonuclease 1;AP Endonuclease 1;APE-1REF-1;Redox Factor-1;APEX1;APE;APE1;APEX;APX;HAP1;REF1
UNIProt ID:
P27695