Recombinant Human ALK-1/ACVRL1 Protein (Fc Tag)(Active)
| Code | Size | Price |
|---|
| PKSH031899-100ug | 100ug | £895.00 |
Quantity:
| PKSH031899-1mg | 1mg | £3,868.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Application: Enzyme-Linked Immunosorbent Assay (ELISA)
Shipping:
The product is shipped on dry ice/blue ice. Upon receipt store it immediately at the storage temperature listed.
Storage:
Lyophilized protein should be stored at < -20°C though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months
Further Information
Abbreviation:
ALK-1;ACVRL1
Accession:
NP_000011.2
Activity:
1. Measured by its ability to bind Human ENG-Fc, latent TGFB1-His, mouse ENG-His in functional Elisa.
2. Measured by its ability to inhibit BMP9 induced alkaline phosphatase production by MC3T3E1 mouse chondrogenic cells. David, L. et al. (2007) Blood 109:1953. The ED50 for this effect is typically 5-15 ng/mL in the presence of 2 ng/mL of recombiant human BMP9.
Background:
Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. On ligand binding, a heteromeric receptor complex forms consisting of two type II and two type I transmembrane serine/threonine kinases. ACVRL1 protein is expressed in certain blood vessels of kidney, spleen, heart and intestine, serving as an important role during vascular development. Mutations in ACVRL1 gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 and vascular disease.
Calculated MW:
37.4 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-hFc
ObservedMW:
45-50 kDa
Purity:
> 97 % as determined by reducing SDS-PAGE.
Sequence:
Met 1-Gln 118
Target Synonym:
Serine/Threonine-Protein Kinase Receptor R3;SKR3;Activin Receptor-Like Kinase 1;ALK-1;TGF-B Superfamily Receptor Type I;TSR-I;ACVRL1;ACVRLK1;ALK1;HHT;HHT2;ORW2;SKR3