Recombinant Human Activin Receptor 2B/ACVR2B Protein (Fc & His Tag)(Active)
| Code | Size | Price |
|---|
| PKSH032041-10ug | 10ug | £406.00 |
Quantity:
| PKSH032041-50ug | 50ug | £500.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Application: Enzyme-Linked Immunosorbent Assay (ELISA)
Shipping:
The product is shipped on dry ice/blue ice. Upon receipt store it immediately at the storage temperature listed.
Storage:
Lyophilized protein should be stored at < -20°C though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months
Further Information
Abbreviation:
Activin Receptor 2B;ACVR2B
Accession:
Q13705
Activity:
Immobilized Human/Mouse/Rat Activin A(Cat: PKSH033807) at 5ug/ml(100 ul/well) can bind Human ACVR2B-His. The ED50 of Human ACVR2B-His is 20.58 ng/ml.
Background:
Activin proteins that belong to the transforming growth factor-beta (TGF-β) superfamily; exert their biological actions by binding to heteromeric receptor complexes of type I and type II serine/threonine kinase receptors. On ligand binding; type I and II receptors form a stable complex; resulting in phosphorylation of type I receptors by type II receptors with constitutive kinase activity; and subsequently initiates the activation of downstream molecules including the endogenous Smads. ActRIIB; also known as ActRIIB; is a type II receptor containing an extracellular domain (ECD); a transmembrane segment; and a cytoplasmic region that includes the kinase domain. ActRIIB is a receptor for activin A; activin B and inhibin A. Multiple ActRIIB isoforms can also be generated; which bind activin isoforms with different affinities.
Calculated MW:
41.3 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from a 0.2 um filtered solution of 20mM PB;150mM NaCl;pH7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-Fc-6His
ObservedMW:
60 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Ser19-Thr134
Target Synonym:
Activin Receptor Type-2B;Activin Receptor Type IIB;ACTR-IIB;ACVR2B;Bone Morphogenetic Protein Receptor Type-2;BMP Type-2 Receptor;BMPR-3;Bone Morphogenetic Protein Receptor Type II;BMP Type II Receptor
UNIProt ID:
Q13705