Recombinant Human Activin RIIA/ACVR2A Protein (Fc & His Tag)(Active)
| Code | Size | Price |
|---|
| PKSH032039-10ug | 10ug | £406.00 |
Quantity:
| PKSH032039-50ug | 50ug | £500.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Application: Enzyme-Linked Immunosorbent Assay (ELISA)
Shipping:
The product is shipped on dry ice/blue ice. Upon receipt store it immediately at the storage temperature listed.
Storage:
Lyophilized protein should be stored at < -20°C though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months
Further Information
Abbreviation:
Activin RIIA;ACVR2A
Accession:
P27037
Activity:
Immobilized Human INHBC-His(Cat: PKSH032587) at 0.8ug/ml(100 ul/well) can bind Human ACVR2A-Fc-6His. The ED50 of Human ACVR2A-Fc-6His is 6. 73 ug/ml.
Background:
Activin Receptor Type-2A is a protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activin type 2 receptor. This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins; composed of a ligand-binding extracellular domain with cysteine-rich region; a transmembrane domain; and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding; resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
Calculated MW:
41.2 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from a 0.2 um filtered solution of 20mM PB;150mM NaCl;pH7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-Fc-6His
ObservedMW:
36 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Ala20-Pro134
Target Synonym:
Activin Receptor Type-2A;Activin Receptor Type IIA;ACTR-IIA;ACTRIIA;ACVR2A;ACVR2
UNIProt ID:
P27037