Recombinant Human ALK4/ACVR1B Protein (His Tag)(Active)
| Code | Size | Price |
|---|
| PKSH032037-10ug | 10ug | £406.00 |
Quantity:
| PKSH032037-50ug | 50ug | £460.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Application: Enzyme-Linked Immunosorbent Assay (ELISA)
Shipping:
The product is shipped on dry ice/blue ice. Upon receipt store it immediately at the storage temperature listed.
Storage:
Lyophilized protein should be stored at < -20°C though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months
Further Information
Abbreviation:
ALK4;ACVR1B
Accession:
P36896
Activity:
Immobilized Human TDGF1-Fc(Cat: PKSH033100) at 10ug/ml(100 ul/well) can bind Human ACVR1B-His. The ED50 of Human ACVR1B-His is 4. 7 ug/ml.
Background:
Activin Receptor Type-1B (ACVR1B) is a single-pass type I membrane protein that belongs to the protein kinase superfamily. ACVR1B contains one GS domain and one protein kinase domain and is expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver. ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B, ACVR2A or ACVR2B activating ACVR1B through phosphorylation of its regulatory GS domain. They go on to recruit the R-SMADs, SMAD2 and SMAD3. ACVR1B also transducers signals of nodal, GDF-1, and Vg1. Mutations in ACVR1B are associated with pituitary tumors.
Calculated MW:
12.5 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from a 0.2 um filtered solution of 20mM PB,150mM NaCl,pH7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-6His
ObservedMW:
18 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Ser24-Glu126
Target Synonym:
Activin Receptor Type-1B;Activin Receptor Type IB;ACTR-IB;Activin Receptor-Like Kinase 4;ALK-4;Serine/Threonine-Protein Kinase Receptor R2;SKR2;ACVR1B;ACVRLK4;ALK4
UNIProt ID:
P36896