Active CASP3 Monoclonal Antibody

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Elabscience
Product Code: E-AB-22115
Product Group: Primary Antibodies
Supplier: Elabscience
CodeSizePrice
E-AB-22115-20uL20uL£125.00
Quantity:
E-AB-22115-60uL60uL£172.00
Quantity:
E-AB-22115-120uL120uL£237.00
Quantity:
E-AB-22115-200uL200uL£344.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Mouse
Antibody Isotype: IgG
Antibody Clonality: Monoclonal
Antibody Clone: Clone:5A2
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunofluorescence (IF)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Images

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Western Blot analysis of 1) Hela, 2) 3T3, 3) Rat brain with Active CASP3 Monoclonal Antibody
2 / 2
Immunohistochemistry of paraffin-embedded Human liver tissue using Active CASP3 Monoclonal Antibody at dilution of 1:200.
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Western Blot analysis of 1) Hela, 2) 3T3, 3) Rat brain with Active CASP3 Monoclonal Antibody
Immunohistochemistry of paraffin-embedded Human liver tissue using Active CASP3 Monoclonal Antibody at dilution of 1:200.

Documents

Further Information

Abbreviation:
Active Caspase-3
Background:
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.
Buffer:
PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:1000, IHC 1:100-1:200, IF 1:100-1:200
Immunogen:
Recombinant Protein
ObservedMW:
17kDa
Purification method:
Protein A purification
Target Synonym:
A830040C14Rik;Apopain;CASP-3;CASP3;CASP3;Casp3a;Caspase 3;Caspase 3;apoptosis-related cysteine peptidase;Caspase 3;apoptosis-related cysteine protease;Caspase 3;apoptosis-related cysteine protease a;Caspase-3 subunit p12;CC3;CPP-32;CPP32;CPP32B;Cysteine protease CPP32;EC 3.4.22.56;LICE;mldy;OTTHUMP00000165052;OTTHUMP00000165053;OTTHUMP00000165054;PARP cleavage protease;Procaspase3;Protein Yama;SCA 1;SCA-1;SREBP cleavage activity 1;Yama
UNIProt ID:
P42574

References

  • https://www.sciencedirect.com/science/article/pii/S2162253122003006
  • https://www.mdpi.com/1806946
  • https://pubs.rsc.org/en/content/articlelanding/2021/fo/d1fo01547h
  • https://www.sciencedirect.com/science/article/pii/S1382668920300880
  • https://www.sciencedirect.com/science/article/pii/S0161813X18304170
  • https://www.spandidos-publications.com/10.3892/ol.2018.9635?text=abstract
  • https://link.springer.com/article/10.1134/S0022093021060120