Catenin beta Monoclonal Antibody

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Elabscience
Product Code: E-AB-22111
Product Group: Primary Antibodies
Supplier: Elabscience
CodeSizePrice
E-AB-22111-20uL20uL£125.00
Quantity:
E-AB-22111-60uL60uL£172.00
Quantity:
E-AB-22111-120uL120uL£237.00
Quantity:
E-AB-22111-200uL200uL£344.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Mouse
Antibody Isotype: IgG
Antibody Clonality: Monoclonal
Antibody Clone: Clone:2E4
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunofluorescence (IF)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Images

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Western Blot analysis of 1) Hela, 2) 293T, 3) Mouse liver, 4) Rat liver with Catenin beta Monoclonal Antibody
2 / 2
Immunohistochemistry of paraffin-embedded Mouse kidney tissue using Catenin beta Monoclonal Antibody at dilution of 1:200.
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Western Blot analysis of 1) Hela, 2) 293T, 3) Mouse liver, 4) Rat liver with Catenin beta Monoclonal Antibody
Immunohistochemistry of paraffin-embedded Mouse kidney tissue using Catenin beta Monoclonal Antibody at dilution of 1:200.

Documents

Further Information

Abbreviation:
Catenin-β
Background:
Key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes.Involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
Buffer:
PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:100-1:300, IF 1:100-1:300
Immunogen:
Recombinant Protein
ObservedMW:
92kDa
Purification method:
Protein A purification
Target Synonym:
Beta catenin;Beta-catenin;Cadherin associated protein;Catenin (cadherin associated protein);beta 1;88kDa;Catenin beta 1;Catenin beta-1;CATNB;CHBCAT;CTNB1;CTNNB;CTNNB1;DKFZp686D02253;FLJ25606;FLJ37923;OTTHUMP00000162082;OTTHUMP00000165222;OTTHUMP00000165223;OTTHUMP00000209288;OTTHUMP00000209289
UNIProt ID:
P35222

References

  • https://www.frontiersin.org/articles/10.3389/fonc.2021.669560/full