Phospho-p70 S6 kinase alpha (Ser418) Polyclonal Antibody

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Elabscience
Product Code: E-AB-21476
Product Group: Primary Antibodies
Supplier: Elabscience
CodeSizePrice
E-AB-21476-20uL20uL£125.00
Quantity:
E-AB-21476-60uL60uL£172.00
Quantity:
E-AB-21476-120uL120uL£237.00
Quantity:
E-AB-21476-200uL200uL£344.00
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Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Images

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Western Blot analysis of HT-29 serum 20% 15' cells using Phospho-p70 S6 kinase alpha (Ser418) Polyclonal Antibody at dilution of 1:1000
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Western Blot analysis of HT-29 serum 20% 15' cells using Phospho-p70 S6 kinase alpha (Ser418) Polyclonal Antibody at dilution of 1:1000

Documents

Further Information

Abbreviation:
p70 S6 kinase α (phospho Ser418)
Background:
P70 S6 Kinase alpha is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases and contains 2 non-identical kinase catalytic domains. It phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein is activated by serine/threonine phosphorylation and protein kinase C and inactivated by type 2A phosphatase. Activation leads to an increase in protein synthesis and cell proliferation. Overexpression of this kinase is involved in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized.
Buffer:
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Calculated MW:
59kDa
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:20000
Immunogen:
Synthesized peptide derived from human p70 S6 kinase α around the phosphorylation site of Ser418
ObservedMW:
60kDa
Purification method:
Affinity purification
Target Synonym:
70 kDa ribosomal protein S6 kinase 1;KS6B1;p70 alpha;P70 beta 1;p70 ribosomal S6 kinase alpha;p70 ribosomal S6 kinase beta 1;p70 S6 kinase alpha;P70 S6 Kinase;p70 S6 kinase;alpha 1;p70 S6 kinase;alpha 2;p70 S6K;p70 S6K-alpha;p70 S6KA;p70(S6K) alpha;p70(S6K)-alpha;p70-alpha;p70-S6K 1;p70-S6K;P70S6K;P70S6K1;p70S6Kb;PS6K;Ribosomal protein S6 kinase 70kDa polypeptide 1;Ribosomal protein S6 kinase beta 1;Ribosomal protein S6 kinase beta-1;Ribosomal protein S6 kinase I;RPS6KB1;S6K;S6K-beta-1;S6K1;Serine/threonine kinase 14 alpha;Serine/threonine-protein kinase 14A;STK14A
UNIProt ID:
P23443