MMP2 Monoclonal Antibody

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Elabscience
Product Code: E-AB-22242
Product Group: Primary Antibodies
Supplier: Elabscience
CodeSizePrice
E-AB-22242-20uL20uL£125.00
Quantity:
E-AB-22242-60uL60uL£172.00
Quantity:
E-AB-22242-120uL120uL£237.00
Quantity:
E-AB-22242-200uL200uL£344.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Mouse
Antibody Isotype: IgG
Antibody Clonality: Monoclonal
Antibody Clone: Clone:1H1
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application: Immunohistochemistry- Paraffin Embedded (IHC-P)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Images

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Immunohistochemistry of paraffin-embedded Human breast carcinoma tissue using MMP2 Monoclonal Antibody at dilution of 1:200.
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Immunohistochemistry of paraffin-embedded Human breast carcinoma tissue using MMP2 Monoclonal Antibody at dilution of 1:200.

Documents

Further Information

Abbreviation:
MMP2
Background:
Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro.PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels.
Buffer:
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:100-200
Immunogen:
Synthetic Peptide of MMP2
Purification method:
Protein A purification
Target Synonym:
72 kDa gelatinase;72kD type IV collagenase;CLG 4;CLG 4A;CLG4;CLG4A;Collagenase Type 4 alpha;Collagenase type IV A;Gelatinase A;Gelatinase alpha;Gelatinase neutrophil;Matrix metallopeptidase 2 gelatinase A 72kDa gelatinase 72kDa type IV collagenase;Matrix metalloproteinase 2 (gelatinase A;72kDa gelatinase;72kDa type IV collagenase);Matrix Metalloproteinase 2;Matrix metalloproteinase II;Matrix metalloproteinase-2;MMP 2;MMP II;MMP-2;MMP2;MMP2;MONA;Neutrophil gelatinase;PEX;TBE 1;TBE-1
UNIProt ID:
P08253