SGK1 Monoclonal Antibody
| Code | Size | Price |
|---|
| E-AB-22207-20uL | 20uL | £125.00 |
Quantity:
| E-AB-22207-60uL | 60uL | £172.00 |
Quantity:
| E-AB-22207-120uL | 120uL | £237.00 |
Quantity:
| E-AB-22207-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG
Antibody Clonality: Monoclonal
Antibody Clone: Clone:4D12
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Immunohistochemistry- Paraffin Embedded (IHC-P)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
SGK1 Mouse (4D12)
Background:
Protein kinase that plays an important role in cellular stress response. Activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic FOXO3A. Phosphorylates NEDD4L, which leads to its inactivation and to the subsequent activation of various channels and transporters such as ENaC, KCNA3/Kv1.3 or EAAT1. Isoform 2 exhibited a greater effect on cell plasma membrane expression of ENaC and Na(+) transport than isoform 1.
Buffer:
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:100-200
Immunogen:
Synthetic Peptide of SGK1
Purification method:
Protein A purification
Target Synonym:
OTTHUMP00000017247;Serine/threonine protein kinase SGK;Serine/threonine protein kinase Sgk1;Serine/threonine-protein kinase Sgk1;Serum and glucocorticoid regulated kinase;Serum/glucocorticoid regulated kinase 1;Serum/glucocorticoid regulated kinase;Serum/glucocorticoid-regulated kinase 1;SGK 1;SGK;SGK1;Sgk1 variant i3;SGK1
UNIProt ID:
O00141