p70 S6 kinase alpha Monoclonal Antibody
| Code | Size | Price |
|---|
| E-AB-22198-20uL | 20uL | £125.00 |
Quantity:
| E-AB-22198-60uL | 60uL | £172.00 |
Quantity:
| E-AB-22198-120uL | 120uL | £237.00 |
Quantity:
| E-AB-22198-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG
Antibody Clonality: Monoclonal
Antibody Clone: Clone:1C7
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Immunohistochemistry- Paraffin Embedded (IHC-P)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
p70 S6 kinase alpha
Background:
P70 S6 Kinase alpha is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases and contains 2 non-identical kinase catalytic domains. It phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein is activated by serine/threonine phosphorylation and protein kinase C and inactivated by type 2A phosphatase. Activation leads to an increase in protein synthesis and cell proliferation. Overexpression of this kinase is involved in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized.
Buffer:
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:100-200
Immunogen:
Recombinant Protein of P70 S6 Kinase of RPS6KB1
Purification method:
Protein A purification
Target Synonym:
70 kDa ribosomal protein S6 kinase 1;KS6B1;p70 alpha;P70 beta 1;p70 ribosomal S6 kinase alpha;p70 ribosomal S6 kinase beta 1;p70 S6 kinase alpha;P70 S6 Kinase;p70 S6 kinase;alpha 1;p70 S6 kinase;alpha 2;p70 S6K;p70 S6K-alpha;p70 S6KA;p70(S6K) alpha;p70(S6K)-alpha;p70-alpha;p70-S6K 1;p70-S6K;P70S6K;P70S6K1;p70S6Kb;PS6K;Ribosomal protein S6 kinase 70kDa polypeptide 1;Ribosomal protein S6 kinase beta 1;Ribosomal protein S6 kinase beta-1;Ribosomal protein S6 kinase I;RPS6KB1;S6K;S6K-beta-1;S6K1;Serine/threonine kinase 14 alpha;Serine/threonine-protein kinase 14A;STK14A
UNIProt ID:
P23443