MAP2K2 Monoclonal Antibody

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Elabscience
Product Code: E-AB-22163
Product Group: Primary Antibodies
Supplier: Elabscience
CodeSizePrice
E-AB-22163-20uL20uL£125.00
Quantity:
E-AB-22163-60uL60uL£172.00
Quantity:
E-AB-22163-120uL120uL£237.00
Quantity:
E-AB-22163-200uL200uL£344.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Mouse
Antibody Isotype: IgG
Antibody Clonality: Monoclonal
Antibody Clone: 7D11
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application: Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Images

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Western Blot analysis of 1) Hela, 2) 3T3, 3) Rat brain using MAP2K2 Monoclonal Antibody at dilution of 1:2000.
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Western Blot analysis of 1) Hela, 2) 3T3, 3) Rat brain using MAP2K2 Monoclonal Antibody at dilution of 1:2000.

Documents

Further Information

Abbreviation:
MEK2
Background:
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.
Buffer:
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:100-1:300, IP 1:200-1:500, ELISA 1:10000
Immunogen:
Synthesized peptide derived from human MEK-2 around the non-phosphorylation site of T394.
ObservedMW:
45kDa
Purification method:
Protein A purification
Target Synonym:
Cardiofaciocutaneous syndrome;CFC syndrome;CFC4;Dual specificity mitogen activated protein kinase kinase 2;Dual specificity mitogen-activated protein kinase kinase 2;ERK activator kinase 2;FLJ26075;MAP kinase kinase 2;map2k2;MAPK / ERK kinase 2;MAPK/ERK kinase 2;MAPKK 2;MAPKK2;MEK 2;MEK2;Microtubule associated protein kinase kinase 2;Mitogen activated protein kinase kinase 2;Mitogen activated protein kinase kinase 2 p45;MKK 2;MKK2;MP2K2;OTTHUMP00000165826;OTTHUMP00000165827;PRKMK 2;PRKMK2
UNIProt ID:
P36507