TNF alpha Monoclonal Antibody

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Elabscience
Product Code: E-AB-22159
Product Group: Primary Antibodies
Supplier: Elabscience
CodeSizePrice
E-AB-22159-20uL20uL£125.00
Quantity:
E-AB-22159-60uL60uL£172.00
Quantity:
E-AB-22159-120uL120uL£237.00
Quantity:
E-AB-22159-200uL200uL£344.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Mouse
Antibody Isotype: IgG
Antibody Clonality: Monoclonal
Antibody Clone: Q34
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Images

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Western Blot analysis of Recombinant Human TNF a Protein using TNF alpha Monoclonal Antibody at dilution of 1:2000.
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Immunohistochemistry of paraffin-embedded Human tonsil tissue using TNF alpha Monoclonal Antibody at dilution of 1:50.
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Western Blot analysis of Recombinant Human TNF a Protein using TNF alpha Monoclonal Antibody at dilution of 1:2000.
Immunohistochemistry of paraffin-embedded Human tonsil tissue using TNF alpha Monoclonal Antibody at dilution of 1:50.

Documents

Further Information

Abbreviation:
TNF α
Background:
TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
Buffer:
PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:1000-1:3000, IHC 1:50-1:200
Immunogen:
Synthetic Peptide
ObservedMW:
17,25kDa
Purification method:
Protein A purification
Target Synonym:
APC1;APC1 protein;Cachectin;DIF;Differentiation inducing factor;Macrophage cytotoxic factor;Tnf;TNF superfamily;member 2;TNF;macrophage derived;TNF;monocyte derived;TNF-a;TNF-alpha;TNFA;TNFA;TNFSF2;Tumor necrosis factor alpha;Tumor necrosis factor;Tumor necrosis factor ligand superfamily member 2;Tumor Necrosis Factor;Membrane Form;Tumor necrosis factor;soluble form
UNIProt ID:
P01375

References

  • https://www.sciencedirect.com/science/article/pii/S0024320521008626
  • https://www.sciencedirect.com/science/article/pii/S0024320521008730