Phospho-ATM (Ser1981) Polyclonal Antibody

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Elabscience
Product Code: E-AB-21540
Product Group: Primary Antibodies
Supplier: Elabscience
CodeSizePrice
E-AB-21540-20uL20uL£125.00
Quantity:
E-AB-21540-60uL60uL£172.00
Quantity:
E-AB-21540-120uL120uL£237.00
Quantity:
E-AB-21540-200uL200uL£344.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Documents

Further Information

Abbreviation:
Atm (phospho Ser1981)
Background:
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.
Buffer:
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:50-1:200, ELISA 1:5000-1:20000
Immunogen:
Synthesized peptide derived from human Atm around the phosphorylation site of Ser1981
ObservedMW:
350kDa
Purification method:
Affinity purification
Target Synonym:
A-T mutated;A-T mutated homolog;AT mutated;AT1;ATA;Ataxia telangiectasia mutated;Ataxia telangiectasia mutated gene;Ataxia telangiectasia mutated homolog (human);Ataxia telangiectasia mutated homolog;ATC;ATD;ATDC;ATE;ATM;ATM serine/threonine kinase;ATM;DKFZp781A0353;MGC74674;OTTHUMP00000232981;Serine protein kinase ATM;Serine-protein kinase ATM;Serine/threonine-protein kinase ATM;Tefu;TEL1;TEL1;telomere maintenance 1;homolog;TELO1;Telomere fusion protein
UNIProt ID:
Q13315