TTR Monoclonal Antibody

TTR Mouse (3B5)

This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.

PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

1 mg/mL

Unconjugated

WB 1:500-2000, IHC 1:50-300

Recombinant Protein of TTR

16kDa

Protein A purification

Amyloid polyneuropathy;Amyloidosis I;ATTR;Carpal tunnel syndrome 1;CTS;CTS1;Dysprealbuminemic euthyroidal hyperthyroxinemia;Dystransthyretinemic hyperthyroxinemia;Epididymis luminal protein 111;HEL111;HsT2651;PALB;Prealbumin amyloidosis type I;Prealbumin;Prealbumin Thyroxine-binding;Senile systemic amyloidosis;TBPA;Thyroxine binding prealbumin;Transthyretin;TTHY;TTR;TTR protein

P02766