Recombinant Human PDGFRB/CD140b Protein (His Tag)(Active)
| Code | Size | Price |
|---|
| PKSH031557-100ug | 100ug | £615.00 |
Quantity:
| PKSH031557-1mg | 1mg | £3,588.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Application: Enzyme-Linked Immunosorbent Assay (ELISA)
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
Samples are stable for up to twelve months from date of receipt at -70°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Further Information
Abbreviation:
PDGFRB;CD140b
Accession:
NP_002600.1
Activity:
Immobilized PDGFRβ-His at 10 ug/ml (100 ul/well) can bind Cynomolgus PDGFB, The EC50 of Cynomolgus PDGFB is 3-8 ng/ml.
Background:
The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD140b, also known as PDGFRB, is a member of the CD system. CD140b is a cell surface tyrosine kinase receptor essencial for development interacting with the platelet-derived growth factors (PDGFs) which serves as mitogens for mesenchymal cells. CD140b can bind with platelet-derived growth factor (PDGF)-B, that are secreted by tumors and phosphorylation of PDGFR-β was correlated with depth of cancer invasion at statistically significant level.
Calculated MW:
57.6 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-His
ObservedMW:
95-100 kDa
Purity:
> 90 % as determined by reducing SDS-PAGE.
Sequence:
Met 1-Lys 531
Target Synonym:
Platelet-Derived Growth Factor Receptor Beta;PDGF-R-Beta;PDGFR-Beta;Beta Platelet-Derived Growth Factor Receptor;Beta-Type Platelet-Derived Growth Factor Receptor;CD140 Antigen-Like Family Member B;Platelet-Derived Growth Factor Receptor 1;PDGFR-1;CD140b;PDGFRB;PDGFR;PDGFR1;CD140B;IBGC4;IMF1;JTK12;KOGS;PENTT