XBP1 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-10674-20uL | 20uL | £125.00 |
Quantity:
| E-AB-10674-60uL | 60uL | £172.00 |
Quantity:
| E-AB-10674-120uL | 120uL | £237.00 |
Quantity:
| E-AB-10674-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
XBP1
Background:
This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Concentration:
0.2 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:50-1:200
Immunogen:
Recombinant protein of human XBP1
Purification method:
Affinity purification
Target Synonym:
Tax responsive element binding protein 5;Tax-responsive element-binding protein 5;TREB5;X box binding protein 1;X box binding protein 2;X-box-binding protein 1;XBP 1;XBP-1;XBP1;XBP1;XBP2
UNIProt ID:
P17861