TXNIP Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-17496-20uL | 20uL | £125.00 |
Quantity:
| E-AB-17496-60uL | 60uL | £172.00 |
Quantity:
| E-AB-17496-120uL | 120uL | £237.00 |
Quantity:
| E-AB-17496-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
TXNIP
Background:
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Concentration:
1.9 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:30-150, ELISA 1:2000-10000
Immunogen:
Synthetic peptide of human TXNIP
Purification method:
Affinity purification
Target Synonym:
THIF;VDUP1;HHCPA78;EST01027
UNIProt ID:
Q9H3M7