TNF alpha Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-33121-20uL | 20uL | £125.00 |
Quantity:
| E-AB-33121-60uL | 60uL | £172.00 |
Quantity:
| E-AB-33121-120uL | 120uL | £237.00 |
Quantity:
| E-AB-33121-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
TNF-α
Background:
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.
Buffer:
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Calculated MW:
26kDa
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:10000
Immunogen:
Synthesized peptide derived from the Internal region of human TNF-α
ObservedMW:
16kDa
Purification method:
Affinity purification
Target Synonym:
APC1;APC1 protein;Cachectin;DIF;Differentiation inducing factor;Macrophage cytotoxic factor;Tnf;TNF superfamily;member 2;TNF;macrophage derived;TNF;monocyte derived;TNF-a;TNF-alpha;TNFA;TNFA;TNFSF2;Tumor necrosis factor alpha;Tumor necrosis factor;Tumor necrosis factor ligand superfamily member 2;Tumor Necrosis Factor;Membrane Form;Tumor necrosis factor;soluble form
UNIProt ID:
P01375
References
- https://www.nature.com/articles/s41590-022-01166-6
- https://academic.oup.com/endo/advance-article-abstract/doi/10.1210/endocr/bqac203/6881427