STAT1 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-40052-20uL | 20uL | £120.00 |
Quantity:
| E-AB-40052-60uL | 60uL | £160.00 |
Quantity:
| E-AB-40052-120uL | 120uL | £230.00 |
Quantity:
| E-AB-40052-200uL | 200uL | £331.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Rat
Applications:
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
STAT1
Background:
Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.
Buffer:
PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.
Calculated MW:
87kDa
Concentration:
2 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:1000, IHC 1:50-1:100
Immunogen:
Recombinant human Zinc finger protein SNAI1 protein
ObservedMW:
87kDa
Purification method:
Affinity purification
Target Synonym:
Signal transducer and activator of transcription 1 91kD;CANDF7;DKFZp686B04100;IMD31A;IMD31B;IMD31C;ISGF 3;ISGF-3;OTTHUMP00000163552;OTTHUMP00000165046;OTTHUMP00000165047;OTTHUMP00000205845;Signal transducer and activator of transcription 1 91kDa;Signal transducer and activator of transcription 1;Signal transducer and activator of transcription 1;91kD;Signal transducer and activator of transcription 1-alpha/beta;STAT 1;Stat1;STAT1;STAT91;Transcription factor ISGF 3 components p91 p84;Transcription factor ISGF-3 components p91/p84
UNIProt ID:
P42224