SRGAP3 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-11600-20uL | 20uL | £125.00 |
Quantity:
| E-AB-11600-60uL | 60uL | £172.00 |
Quantity:
| E-AB-11600-120uL | 120uL | £237.00 |
Quantity:
| E-AB-11600-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
SRGAP3
Background:
SRGAP3 is a 1099 amino acid protein containing 1 FCH domain, 1 Rho-GAP domain and 1 SH3 domain. Expressed highly in brain, and in lower levels in kidney, WRP is thought to play a role in cell migration through its interaction with Cdc42 and Rac1. Cdc42 and Rac1 are two intracellular signaling proteins that regulate the multistep cell migration process. WRP downregulates Cdc42 and Rac1 activity, thereby impairing actin and microtubule dynamics, the formation of protrusions, and total cell migration. Defects in the gene encoding WRP have been linked to severe idiopathic mental retardation. Three isoforms of WRP exist as a result of alternative splicing events.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Concentration:
0.6 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:25-1:100
Immunogen:
Recombinant protein of human SRGAP3
Purification method:
Affinity purification
Target Synonym:
ARHGAP 14;ARHGAP14;Gbi;ME GAP;MEGAP;Mental disorder associated GAP;Mental disorder-associated GAP;Rho GTPase activating protein 14;Rho GTPase-activating protein 14;SLIT ROBO Rho GTPase activating protein 3;SLIT-ROBO Rho GTPase-activating protein 3;srGAP 2;srGAP 3;srGAP2;srGAP3;SRGP 2;SRGP2;SRGP3;WAVE associated Rac GTPase activating protein;WAVE-associated Rac GTPase-activating protein;WRP
UNIProt ID:
O43295
References
- https://www.pnas.org/content/118/26/e2019167118.short