SPAG1 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-15858-20uL | 20uL | £125.00 |
Quantity:
| E-AB-15858-60uL | 60uL | £172.00 |
Quantity:
| E-AB-15858-120uL | 120uL | £237.00 |
Quantity:
| E-AB-15858-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
SPAG1
Background:
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Calculated MW:
104kDa
Concentration:
0.3 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000
Immunogen:
Synthetic peptide of human SPAG1
Purification method:
Affinity purification
Target Synonym:
CILD28;FLJ32920;HSD-3.8;Infertility related sperm protein Spag 1;SP75;SPAG1;Sperm associated antigen 1;Tetratricopeptide repeat-containing protein;TPIS;TPR containing protein involved in spermatogenesis
UNIProt ID:
Q07617