SMAD7 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-15853-20uL | 20uL | £125.00 |
Quantity:
| E-AB-15853-60uL | 60uL | £172.00 |
Quantity:
| E-AB-15853-120uL | 120uL | £237.00 |
Quantity:
| E-AB-15853-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
SMAD7
Background:
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Concentration:
0.4 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:50-1:200
Immunogen:
Synthetic peptide of human SMAD7
Purification method:
Affinity purification
Target Synonym:
CRCS3;FLJ16482;hSMAD 7;hSMAD7;MAD (mothers against decapentaplegic Drosophila) homolog 7;MAD;Mad homolog 7;MAD homolog 8;MAD mothers against decapentaplegic homolog 7;MADH 7;MADH 8;MADH6;MADH8;Mothers Against Decapentaplegic Drosophila Homolog of 6;Mothers Against Decapentaplegic Drosophila Homolog of 7;Mothers against decapentaplegic homolog 7;Mothers against decapentaplegic homolog 8;Mothers against DPP homolog 7;Mothers against DPP homolog 8;SMA- AND MAD-RELATED PROTEIN 7;SMAD 7;SMAD;SMAD family member 7;SMAD;mothers against DPP homolog 7 (Drosophila);SMAD;mothers against DPP homolog 7;SMAD6;Smad7;SMAD7
UNIProt ID:
O15105